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Letters to Nature
Nature 217, 64 - 65 (06 January 1968); doi:10.1038/217064a0

Deficiency of Erythrocyte Nicotinamide Adenine Dinucleotide Nucleosidase (NADase) Activity in the Negro

WON G. NG, GEORGE N. DONNELL & W. R. BERGREN

Departments of Biochemistry and Pediatrics, School of Medicine, University of Southern California, and Children's Hospital of Los Angeles.

IT has been shown that haemolysates from newborn infants differ from those of adults in that UDPgalactose-4-epimerase (epimerase) is active in the absence of exogenous nicotinamide adenine dinucleotide (NAD) (ref. 1). The apparent NAD-independent epimerase activity results from low or absent NADase activity in the haemolysates from newborns2.

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