Nature 216, 1225 - 1226 (23 December 1967); doi:10.1038/2161225a0

Effect of Promethazine Hydrochloride on the Release of Gastrin in the Dog

R. DOMBRO & H. RAGINS

Gastrointestinal Research Unit of the Department of Surgery, The Albert Einstein College of Medicine, Bronx, New York.

ANTIHISTAMTNIC drugs do not inhibit acid secretion stimulated by histamine or insulin in the dog, but given intravenously they do suppress the secretory response to endogenous gastrin^1,2. Payne et al. ², after testing several antihistamines, suggested that the specific pharmacological mechanism of this phenomenon was their atropine like (anticholinergic) effect. It is, however, difficult to reconcile this explanation with the fact that the vagal phase of acid secretion, stimulated by insulin hypo-glycaemia, was apparently unaffected by the antihistaminics¹.

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2. Payne, R. A. , Naylor, F. D. , and Kay, A. W. , Brit. J. Surg., 48, 683 (1961). | PubMed | ISI | ChemPort |
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7. Elwin, C. E. , and Uvnas, B. , in Gastrin (edit. by Grossman, M. I.), 79 (U.C.L.A. Forum in Med. Sci. No. 5, University of California Press, 1966).