Nature 216, 375 - 376 (28 October 1967); doi:10.1038/216375a0

Carcinogenicity of Hydrazine and 1,1-Dimethylhydrazine for Mouse Lung

F. J. C. ROE, G. A. GRANT & D. M. MILLICAN

Chester Beatty Research Institute, Fulham Road, London.

BOTH hydrazine itself and 1,1-dimethylhydrazine are known to be hepatotoxic^1–5, but neither compound was investigated for carcinogenicity until Biancifiori and Ribacchi⁶ tested hydrazine sulphate as part of a study of the mechanism of carcinogenesis by the anti-tuberculous drug, isonicotinic acid hydrazide^7,8. These workers reported the induction of pulmonary tumours in 100 per cent of twenty-two female Balb/C mice which survived daily oral treatment with 1.13 mg of hydrazine sulphate for 46 weeks (total dose of hydrazine sulphate, 283 mg).

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