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Letters to Nature
Nature 215, 58-59 (1 July 1967) | doi:10.1038/215058a0; Received 24 April 1967
Secretion of a Chromaffin Granule Protein, Chromogranin, from the Adrenal Gland after Splanchnic Stimulation
H. BLASCHKO, R. S. COMLINE, F. H. SCHNEIDER, MARIAN SILVER & A. D. SMITH
- Physiological Laboratory, University of Cambridge, and Department of Pharmacology, University of Oxford.
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Abstract
Banks and Helle1 have reported that stimulation of the isolated bovine adrenal gland, during retrograde perfusion, releases not only catecholamines but also a soluble protein present in the chromaffin granules; this finding has since been confirmed2,3. We propose the term "chromogranin(s)" as suitable for the soluble protein fractions of the chromaffin granules of the adrenal medulla.
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