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Letters to Nature
Nature 214, 919 - 920 (27 May 1967); doi:10.1038/214919a0

Acute Pharmacology of Melatonin

JACK BARCHAS*, FRANCES DACOSTA & SYDNEY SPECTOR

Laboratory of Clinical Biochemistry and Experimental Therapeutics Branch, National Heart Institute, Bethesda, Maryland.
*Present address: Department of Psychiatry, Stanford Medical Center Palo Alto, California.
Present address: Division of Pharmacology, Food and Drug Administration, Washington.

MELATONIN (N-acetyl-O-methyl serotonin), a pineal compound discovered by Lerner1, may function as a hormone and is known to be extremely active in certain biological systems2–5. We have investigated the acute pharmacological effects of the compound with particular emphasis on the nervous and vascular systems. We find that melatonin has no acute pharmacological effects in the systems studied apart from its effect on sleep mechanisms.

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References

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