Nature 214, 578 - 580 (06 May 1967); doi:10.1038/214578a0

The Vertebrate Epidermal Chalone

W. S. BULLOUGH, E. B. LAURENCE, O. H. IVERSEN & K. ELGJO

Birkbeck College, University of London
Institute of General and Experimental Pathology, University of Oslo

Extracts of vertebrate epidermis contain an antimitotic chemical messenger, called the epidermal chalone, which appears to be of central importance in the control of epidermal mitosis. Other similar chalones have been reported in other tissues. The epidermal chalone is tissue-specific, but it is now shown to be neither species- nor class-specific. This indicates that the epidermal mitotic control mechanisms must be closely similar in all vertebrates from fishes to mammals.

References

1.	Bullough, W. S., Cancer Res., 25, 1683 (1965). | PubMed | ISI | ChemPort |
2.	Elgjo, K., thesis, Univ. Oslo (1966).
3.	Iversen, O. H., Acta Path. Microbiol. Scand., Suppl., 148, 91 (1961). | PubMed |
4.	Iversen, O. H., and Bjerknes, R., Acta Path. Microbiol. Scand., Suppl., 165, 1 (1963).
5.	Mercer, E. H., Brit. Med. Bull., 18, 187 (1962). | PubMed | ISI | ChemPort |
6.	Bullough, W. S., and Laurence, E. B., Exp. Cell Res., 33, 176 (1964). | PubMed | ISI | ChemPort |
7.	Bullough, W. S., and Laurence, E. B., Exp. Cell Res., 35, 629 (1964). | Article | PubMed | ISI | ChemPort |
8.	Bullough, W. S., and Laurence, E. B., Symp. Zool. Soc. Lond., 12, 1 (1964).
9.	Iversen, O. H., Aandahl, E., and Elgjo, K., Acta Path. Microbiol. Scand., 64, 506 (1965). | PubMed | ISI | ChemPort |
10.	Bullough, W. S., Hewett, C. L., and Laurence, E. B., Exp. Cell Res., 36, 192 (1964). | Article | PubMed | ISI | ChemPort |
11.	Bullough, W. S., and Laurence, E. B., Proc. Roy. Soc., B, 151, 517 (1960). | ISI | ChemPort |
12.	Saetren, H., Exp. Cell Res., 11, 229 (1956). | Article | PubMed | ISI | ChemPort |
13.	Saetren, H., Acta Chem. Scand., 17, 889 (1963). | ISI |
14.	Bullough, W. S., and Rytömaa, T., Nature, 205, 573 (1965). | ISI |
15.	Froomberg, D., and Voaden, M., Exp. Eye Res., 5, 1 (1966). | PubMed | ISI | ChemPort |
16.	Bullough, W. S., and Laurence, E. B., Exp. Cell Res., 21, 394 (1960). | Article | ISI |
17.	Iversen, O. H., and Elgjo, K., in Growth Control (edit. by Teir, H., and Rytömaa, T.) (Academic Press, London and New York, in the press).
18.	Bullough, W. S., and Laurence, E. B., Exp. Cell Res., 24, 289 (1961). | Article | ISI |
19.	Bullough, W. S., and Laurence, E. B., in Adv. Biol. Skin Carcinogenesis (edit. by Montagna, W.) (Pergamon Press, London and New York, 1966).