Nature 214, 352 - 355 (22 April 1967); doi:10.1038/214352a0

Axonic and Synaptic Lesions in Neuropsychiatric Disorders

NICHOLAS K. GONATAS

Departments of Neurology and Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Peculiar vesicular structures in the axons and synaptic terminals of neocortex of a 30 month old boy with psychomotor retardation of unknown origin are similar to the changes observed in other human diseases characterized by disorders of memory and learning. Such changes in the architecture of axons and synapses may cause certain disorders the aetiology of which is at present obscure.

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