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| Nature 214, 283 - 284 (15 April 1967); doi:10.1038/214283a0 |
|
Differences in Uridine Diphosphate Galactose-4-Epimerase between Haemolysates of Newborns and of Adults
WON G. NG, GEORGE N. DONNELL, JOAN E. HODGMAN & WILLIAM R. BERGREN
Departments of Biochemistry and of Pediatrics of the School of Medicine, University of Southern California. Children's Hospital of Los Angeles. Los Angeles County General Hospital.
THIS communication presents an observation not yet reported concerning the effect of exogenous nicotinamide adenine dinucleotide (NAD) on the activity of uridine diphosphate galactose-4-epimerase. This enzyme (formerly called galactowaldenase) was first demonstrated in yeast extract by Leloir1. NAD was shown later to be required for activity in a calf liver preparation2. The need for an exogenous supply of NAD was further shown in crude human haemolysates3 and in homogenates of L cells4. It now has been found that haemolysates from newborn infants demonstrate a substantial epimerase activity without the addition of NAD.
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© 1967 Nature Publishing Group
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