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| Nature 213, 822 - 824 (25 February 1967); doi:10.1038/213822a0 |
|
Novel Alterations in Sera from Pseudopregnant and Deciduoma-bearing Rats
J. R. BATTISTO* & M. C. SHELESNYAK
Department of Biodynamics, Weizmann Institute of Science, Rehovoth, Israel.
*Present address: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, New York.
CONSIDERABLE attention has recently been focused on a new serum component of rats which was described by Darcy as being associated with rapid growth of tissue. Although it was not found originally in electrophoretically partitioned sera of healthy adult males or non-pregnant females, the protein was found in sera of foetal, neonatal, tumour-bearing, liver-regenerating, lactating, and pregnant rats1–5. Identified as an alpha-l-glycoprotein, it has been shown to be synthesized by the liver during the acute phase of an inflammatory response6. An apparently identical component is present in the blood of rats experimentally poisoned by cadmium and other metals7 and in rats given single doses of Escherichia coli endotoxin8. A new protein migrating in the region of the alpha globulins has also been described in mice treated with a variety of toxic agents9.
| 1. | Darcy, D. A., Brit. J. Cancer, 11, 137 (1957). | PubMed | ISI | ChemPort | |
| 2. | Beaton, G. H., Selby, A. E., Veen, M. J., and Wright, A. M., J. Biol. Chem., 236, 2005 (1961). | PubMed | ISI | ChemPort | |
| 3. | Heim, W. G., Amer. Zool., 1, 359 (1961). | ISI | |
| 4. | Heim, W. G., Nature, 193, 491 (1962). | PubMed | ISI | ChemPort | |
| 5. | Boffa, G. A., Nadal, C., Zajdela, F., and Fine, J. M., Nature, 203, 1182 (1964). | PubMed | ISI | ChemPort | |
| 6. | Weimer, H. E., Benjamin, D. C., and Darcy, D. A., Nature, 208, 1221 (1965). | PubMed | ISI | ChemPort | |
| 7. | Lawford, D. J., Nature, 187, 946 (1960). | PubMed | ISI | ChemPort | |
| 8. | Lawford, D. J., and White, R. G., Nature, 201, 705 (1964). | PubMed | ISI | ChemPort | |
| 9. | Rowen, R., and Wiest, M. A., J. Exp. Med., 122, 547 (1965). | Article | PubMed | ISI | ChemPort | |
| 10. | Loeb, L., Centrblt. Allg. Path. u. Path. Anat., 18, 563 (1907). |
| 11. | Shelesnyak, M. C., Anat. Rec., 49, 179 (1931). | Article | |
| 12. | Smithies, O., Biochem. J., 71, 585 (1959). | PubMed | ISI | ChemPort | |
| 13. | Shelesnyak, M. C., in Recent Progress in Hormone Research, XIII, 269 (1957). | ChemPort | |
© 1967 Nature Publishing Group
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