Nature 211, 989 (27 August 1966); doi:10.1038/211989a0

Effect of Degraded Carrageenin on Gastric Secretion Stimulated by Histamine and 'Histalog'

JAMES WATT, G. B. EAGLETON & R. MARCUS

Department of Pathology, University of Liverpool.
Clatterbridge Hospital, Bebington, Cheshire.

THERE is some evidence that in the guinea-pig, the oral administration of degraded carrageenin, a sulphated polysaccharide, causes a slight temporary reduction of gastric acidity in response to histamine¹. We have had occasion to study the effect on gastric secretion when degraded carrageenin is administered subcutaneously. The results indicate that carrageenin parenterally has a pronounced inhibitory action on the acid secretory response to histamine but, somewhat paradoxically, not on the secretory response to 'Histalog' (betazole hydrochloride), a structural isomer of histamine.

1. Anderson, W. , Marcus, R. , and Watt, J. , J. Pharm. Pharmacol., 14, 119T (1962).
2. Dragstedt, C. A. , Wells, J. A. , and Rocha E. Silva, M. , Proc. Soc. Exp. Biol. N.Y., 51, 191 (1942). | ChemPort |