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| Nature 210, 104 - 105 (02 April 1966); doi:10.1038/210104b0 |
|
Synergistic Interaction of Kethoxal bis(Thiosemicarbazone) and Cupric Ions in Sarcoma 180
BARBARA A. BOOTH & ALAN C. SARTORELLI
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut.
2-KETO-3-ethoxybutyraldehyde bis (thiosemicarbazone) [kethoxal bis(thiosemicarbazone); KTS], an agent that chelates metals of the first, second and third transition series1, has been reported to be an inhibitor of the growth of several transplanted rodent neoplasms2–5. The anti-neoplastic potency of KTS was enhanced by the presence of either cupric or zinc ions6; however, the preformed cupric chelate was found to be the most potent of several different metal chelates of KTS1,5,7. To investigate the relationship of copper ions to the antineoplastic activity of KTS, the effects of combinations of cupric ions (as cupric chloride) and KTS, both on growth and on the synthesis of nucleic acids and proteins, were measured in sarcoma 180 ascites cells.
- Van Giessen, G. J. , and Petering, H. G. , Abst. Amer. Chem. Soc. Meeting, 13N (1965).
- Petering, H. G. , and Buskirk, H. H. , Fed. Proc., 21, 163 (1962). | ISI |
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- Sartorelli, A. C. , and Booth, B. A. , Fed. Proc., 24, 454 (1965). | ISI |
- Booth, B. A. , and Sartorelli, A. C. (unpublished observations).
- Moutschen-Dahmen, J. , and Moutschen-Dahmen, M. , Experientia, 19, 144 (1963). | PubMed | ChemPort |
- Moutschen, J. , Moës, A. , and Gilot, J. , Experientia, 20, 494 (1964). | PubMed | ChemPort |
- Booth, B. A. , Creasey, W. A. , and Sartorelli, A. C. , Proc. U.S. Nat. Acad. Sci., 52, 1396 (1964). | ChemPort |
- Stoner, R. E. , and Dasler, W. , Clin. Chem., 10, 845 (1964). | PubMed | ISI | ChemPort |
© 1966 Nature Publishing Group
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