Abstract
ALTHOUGH it is now generally conceded, that disaccharides may be absorbed intact at appreciable rates from the lumen of the small intestine, as found for maltose by Waymouth Reid in 1901, very little is known about the factors which affect the process. It is established that in mammals, including human subjects, disaccharides such as lactose, sucrose and maltose undergo hydrolysis at some site in or on the mucosal cells and not in the intestinal lumen1–4. We have now investigated the absorption of some disaccharides by the small intestine of some Amphibia using a system for the perfusion of the mesenteric vascular bed.
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References
Reid, E. W., J. Physiol., 26, 427 (1901).
Cajori, F. A., Amer. J. Physiol., 104, 659 (1933).
Miller, D., and Crane, R., Biochem. Biophys. Acta, 52, 281 (1961).
Chain, E. B., Mansford, K. R. L., and Pocchiari, F., J. Physiol., 154, 39 (1960).
Fisher, R. B., and Parsons, D. S., J. Physiol., 110, 36 (1949).
Dahlqvist, A., Anal. Biochem., 7, 18 (1964).
Miller, D., and Crane, R., Biochim. Biophys. Acta, 52, 293 (1961).
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PARSONS, D., PRICHARD, J. Hydrolysis of Disaccharides during Absorption by the Perfused Small Intestine of Amphibia. Nature 208, 1097–1098 (1965). https://doi.org/10.1038/2081097a0
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DOI: https://doi.org/10.1038/2081097a0
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