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Nature 206, 1052 (05 June 1965); doi:10.1038/2061052a0

Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine

FR. FRANZEN & H. Gross

5 Köln-Marienburg, Ulmenallee 3.

TRYPTAMINE is a normal constituent of human urine1–5; about 30–120 µg of the amine are excreted per 24 h. In blood, tryptamine has hitherto been demonstrated only qualitatively and under pathological conditions in a carcinoid patient6. There is no information about an occurrence of N,N-dimethyltryptamine in human beings. N,N-dimethyl-5-hydroxytryptamine (= Bufotenin) was demonstrated qualitatively as a constituent of normal human urine4,7; in children an excretion of 0–0.03 µg amine/100 mg creatinine has been found with, at most, semi-quantitative methods4. Apparently, N,N-dimethyl-5-hydroxytryptamine was still not demonstrated in blood. 5-Methoxytryptamine has been found in the urine of patients with rheumatic fever8, and that in an order of magnitude of 30–210 µg/24 h.

  1. Rodnight, R. , Biochem. J., 64, 621 (1956). | PubMed | ISI | ChemPort |
  2. Sjoerdsma, A. , Oates, J. A. , Zaltzman, P. , and Udenfriend, S. , J. Pharmacol. Exp. Therap., 126, 217 (1959). | ISI | ChemPort |
  3. Levine, R. J. , Oates, J. A. , Vendsalu, A. , and Sjoerdsma, A. , J. Clin. Endocrinol. Metabol., 22, 1242 (1962). | ISI | ChemPort |
  4. Perry, Th. L. , Shaw, K. N. F. , Walker, D. , and Redlich, D. , Pediatrics, 30, 576 (1962). | ISI | ChemPort |
  5. Perry, Th. L. , Science, 139, 587 (1963). | ISI | ChemPort |
  6. Eccleston, D. , Crawford, T. B. B. , and Ashcroft, G. W. , Nature, 197, 502 (1963). | Article | ISI | ChemPort |
  7. Bumpus, F. M. , and Page, I. H. , J. Biol. Chem., 212, 111 (1955). | PubMed | ISI | ChemPort |
  8. Haddox, Jun., Ch. H. , and Saslaw, M. S. , J. Clin. Invest., 42, 435 (1963). | PubMed | ISI | ChemPort |
  9. Gross, H. , and Franzen, Fr. , Biochem. Z., 340, 403 (1964). | PubMed | ISI | ChemPort |
  10. Gross, H. , and Franzen, Fr. , Biochem. Z. (in the press).
  11. Gross, H. , and Franzen, Fr. , Biochem. Z. (in the press).



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