Nature 205, 605 (06 February 1965); doi:10.1038/205605a0

Oestrogen and Gonadotrophin in the Blood of Dogs during Bone Fracture Healing

A. H. SAID & F. A. SOLIMAN

Department of Veterinary Surgery,
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Cairo, Giza, Egypt, U.A.R.

PREVIOUS reports have dealt with variations in the activity of thyroid glands¹ and changes in the levels of androgens, follicle-stimulating and luteinizing hormones² as a result of bone fracture. The present investigation is concerned with changes in oestrogens and gonadotrophic hormones (FSH and LH) in the blood of dogs during the healing of bone fractures. Twenty-five mature anoestrous non-pregnant female dogs were used. Mid-diaphyseal fractures of the left radius were made by an open technique. Animals were anaesthetized using chloropromazine hydrochloride and thiopental sodium. The radius in the dog was firmly fixed at its proximal and distal extremities to the ulna, which was left intact and acted as a natural splint.