Nature 205, 194 (09 January 1965); doi:10.1038/205194a0

Immune Response induced by RNA-Immuno-carrier extracted from Heterologous Immune Sera

L. MICHELAZZI, I. BALDINI, A. NOVELLI & G. NANNI

Institute of General Pathology, University of Genoa, Italy.

THE importance of nucleoproteins in antibody-globulin production is well known^1,2. In previous experiments^3,4 an evident increase of the content of RNA in the -globulin fraction in immune sera has been observed. The RNA extracted from the serum of immunized rabbits is capable of eliciting in normal rabbits the production of antibodies against the same antigens used for immunizing the animals from which this RNA-immuno-carrier (RNA-I-C) was taken. The following investigations were undertaken to ascertain whether an RNA-I-C extracted from the serum of immunized animals of one species was able to induce antibody production in animals of a different species.

1. Michelazzi, L. , Boll. Ist. Sier. Mil., 29, 28 (1950).
2. Fishman, M. , and Adler, F. L. , J. Exp. Med., 117, 595 (1963). | Article | PubMed | ISI | ChemPort |
3. Michelazzi, L. , Nanni, G. , and Baldini, I. , Reported to Meeting, Soc. Ital. Biol. Sperim. (March 25, 1964).
4. Michelazzi, L. , Nanni, G. , Baldini, I. , and Novelli, A. , Experientia, 20, 447 (1964). | Article | PubMed | ISI | ChemPort |