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| Nature 201, 848 - 849 (22 February 1964); doi:10.1038/201848a0 |
|
Role of Interferon in Viral Interference
ROBERT M. FRIEDMAN*
Pathological Anatomy Branch, National Cancer Institute, Bethesda, Maryland.
*Present address: National Institute for Medical Research, Mill Hill, London, N.W.7.
ACTINOMYCIN D inhibits the production of interferon1. Since the exact role of interferon in the phenomenon of viral interference has not been fully established, the effect of actinomycin D on viral interference was tested. The present results show that when actinomycin D inhibited interferon production by a heat-inactivated arbovirus, it also reversed viral interference by the virus.
- Heller, E. , Biochem. J., 87, 18 (1963); Virology (in the press).
- Gifford, G. E. , and Heller, E. , Nature, 200, 50 (1963). | Article | PubMed | ISI | ChemPort |
- Lindemann, J. , and Gifford, G. E. , Virology, 19, 302 (1963). | Article | PubMed | ISI | ChemPort |
- Ruiz-Gomez, R. , and Isaacs, A. , Virology, 19, 1 (1963). | Article | PubMed | ChemPort |
- Kilbourne, E. D. , Smart, K. M. , and Pokorny, B. A. , Nature, 190, 650 (1961). | Article | PubMed | ISI | ChemPort |
- Kilbourne, E. D. , J. Exp. Med., 106, 863 (1957). | Article | PubMed | ISI | ChemPort |
© 1964 Nature Publishing Group
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