Abstract
THE ‘Castrix’ molecule (2-chloro-4-methyl-6-dimethylaminopyrimidin)1,2 resembles the vitamin B6-antagonist toxopyrimidin. In rodents poisoned with this rodenticide the symptoms are an initial depression followed in 40–60 min by a ‘search and flight reaction’, spastieity, and tonicclonic seizures, often with tongue-bite. Sound and touch aggravate the severity of the seizures, which may end with death from respiratory failure, dependent on dosage. Survival for more than 5 h usually results in total recovery within 24 h. As these symptoms are almost identical with those seen after administration of certain carbonyl trapping agents and vitamin B6-antagonists3–6 we tried vitamin B6 as an antidote.
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KARLOG, O., KNUDSEN, E. Vitamin B6 as an Antidote against the Rodenticide ‘Castrix’ (2-Chloro-4-methyl-6-dimethylaminopyrimidin). Nature 200, 790 (1963). https://doi.org/10.1038/200790a0
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DOI: https://doi.org/10.1038/200790a0
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