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Letters to Nature
Nature 199, 1298-1299 (28 September 1963) | doi:10.1038/1991298a0
Thyroid-adrenocortical Antagonism and Histamine Metabolism
P. S. J. SPENCER* & G. B. WEST
- Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, London, W.C.1.
- *Present address: Research Division of Allen and Hanburys, Ltd., Ware, Herts.
Abstract
Bjurö, Westling and Wetterqvist1 have recently suggested that there is a direct antagonism between the actions of the adreno-corticosteroids and those of the thyroid hormones on histamine metabolism in rats. Their results were obtained, chiefly, by estimating the urinary output of histamine. We have been investigating this problem over the past two years2,3 and conclude that this action of the thyroid hormones is mediated indirectly through their effects on the level of adrenocorticosteroids in the body. Thus only the glucocorticosteroids exert a direct effect on histamine metabolism, their blood concentrations determining the level of histamine sensitivity and of other aspects of histamine metabolism.
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