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Letters to Nature
Nature 198, 88-89 (6 April 1963) | doi:10.1038/198088b0
Structure of Bilirubin
J. FOG & E. JELLUM
- Institute for Medical Biochemistry, University of Oslo.
- Institute for Aviation Medicine, Blindern Oslo.
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Abstract
CONJUGATED bilirubins (esters) are formed within the liver cells from bilirubin and glucuronic or sulphuric acid. These compounds are very unstable because of the highly reactive central methylene bridge. They are oxidized rapidly by the air and react immediately with diazotized sulphanilic acid. Contrary to the esters, pure bilirubin is relatively stable and reacts with the diazoreagent only when an accelerator is added.
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