Nature 197, 1304 (30 March 1963); doi:10.1038/1971304a0

Stimulation of Insulin Secretion in vitro by Adenosine Triphosphate

J. L. R-CANDELA, D. MARTIN-HERNANDEZ & T. CASTILLA-CORTAZAR

Instituto G. Marañon, Velazquez 138, Madrid 6.

WE have already shown that the metabolites (glucose, citrate, -hydroxybutyrate), the final function of which is the production of energy in the P form^1,2, give place to release of insulin in vitro when they are added to the incubation buffer surrounding slices of pancreas. For this reason, we considered it interesting to determine if ATP when added to the incubation buffer produces any effect on the release of insulin, although what is generally accepted is that the metabolic processes in which this nucleotide takes part are intracellular.

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