Nature 195, 712 (18 August 1962); doi:10.1038/195712a0

Correlation of the Effects of Insulin and of Muscular Contraction in vitro on Uptake of Glucose by the Frog

R. R-CANDELA, M. RODRIGUEZ LOPEZ, T. CASTILLA-CORTAZAR & J. L. R-CANDELA

Instituto 'G. Marañón', Velazquez 138, Madrid, 6.

Heimreich and Cori¹ and later R-Candela² among others have shown that the specificity to sensitive sugars is similar both with insulin and muscular contraction. On the other hand, the great resistance of toads to insulin injections is known from the work of Rapela et al. ³. We have confirmed this finding in frogs injected with up to 40 U./100 gm. without showing any signs of hypoglycæmia.

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