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| Nature 192, 881 - 882 (02 December 1961); doi:10.1038/192881a0 |
|
Protection by Antioxidants against Lethal Doses of Carbon Tetrachloride
C. H. GALLAGHER
Division of Animal Health, Commonwealth Scientific and Industrial Research Organization, McMaster Laboratory, New South Wales.
Rees, Spector and Sinha1 have shown that 'Phenergan', 10-(2-dimethylamino-isopropyl) phenothiazine hydrochloride, protects against necrosis of liver cells in rats dosed with carbon tetrachloride. Afterwards, Gallagher and Rees2 found that 'Phenergan' maintained normal concentrations of oxidized pyridine nucleotides in the liver despite the administration of carbon tetrachloride. These findings, together with those of McLean3,4 and Gallagher, Gupta, Judah and Rees5 that 'Phenergan' protects rats against liver necrosis due either to vitamin E deficiency or to administration of thioacetamide, suggested that 'Phenergan' operates on a general metabolic mechanism involved in the maintenance of cellular and mitochondrial integrity. The value of 'Phenergan' as an alternative to vitamin E indicated that its action might be associated with antioxidant properties. Therefore, the antioxidants6,7 
-tocopherol, sodium selenite and NN
1-diphenyl-p-phenylenediamine were investigated as possible protective agents in carbon tetrachloride poisoning.
- Rees, K. R. , Spector, W. G. , and Sinha, K. P. , J. Path. Bact., 81, 107 (1961). | Article | PubMed | ISI | ChemPort |
- Gallagher, C. H. , and Rees, K. R. , Nature, 187, 148 (1960). | Article | PubMed | ISI | ChemPort |
- McLean, A. E. M. , Nature, 185, 191 (1960). | Article | ISI | ChemPort |
- McLean, A. E. M. , Nature, 185, 936 (1960). | Article | ISI | ChemPort |
- Gallagher, C. H. , Gupta, D. N. , Judah, J. D. , and Rees, K. R. , J. Path. Bact., 72, 193 (1956). | Article | PubMed | ISI | ChemPort |
- Zalkin, H. , Tappel, A. L. , and Jordan, J. P. , Arch. Biochem. Biophys., 91, 117 (1960). | Article | PubMed | ISI | ChemPort |
- Schwarz, K. , Proc. Soc. Exp. Biol. and Med., 99, 20 (1958). | ISI | ChemPort |
© 1961 Nature Publishing Group
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