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Nature 191, 1193 - 1194 (16 September 1961); doi:10.1038/1911193a0

Mechanism of Synthesis of Adenine from Hydrogen Cyanide under Possible Primitive Earth Conditions

J. ORÓ

Chemistry Department, University of Houston, Houston 4, Texas.

IT has recently been shown that adenine and the purine precursors 4-aminoimidazole-5-carboxamidine and formamidine are formed spontaneously from hydrogen cyanide in water–ammonia systems under conditions assumed to have existed on the primitive Earth1.

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  2. Grossman, F. , Cristopher, J. , and Canavan, G. , in Proc. Nat. Sci. Found. Summer Inst. for High School Juniors, 8 (University of Houston, 1960). Oró, J. , Fed. Proc., 20, 352 (1961); Proc. Fifth Intern. Cong. Bioehem., Moscow (in the press).
  3. Völker, T. , Angew. Chem., 62, 728 (1957); Angew. Chem., 72, 379 (1960).
  4. Lange, O. , Ber., 6, 99 (1873); Wippermann, R. , Ber., 7, 767 (1874). See also: Long, D. A. , and George, W. D. , Proc. Chem. Soc., 285 (1960).
  5. Bredereck, H. , Schmötzer, G. , and Becher, H. S. , Ann., 600, 87 (1956). | ChemPort |
  6. Richter, E. , Loeffler, J. E. , and Taylor, E. C. , J. Amer. Chem. Soc., 82, 3144 (1960). | Article | ISI | ChemPort |
  7. Taylor, E. C. , and Cheng, C. C. , Tetrahedron Letters, No. 12, 9 (1959).



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