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Letters to Nature
Nature 191, 1188 - 1189 (16 September 1961); doi:10.1038/1911188b0

Proposed Use of Magnetic Fields in Electron Microscopic Radioautography

LUCIEN G. CARO

The Rockefeller Institute, New York 21.

THE use of strong magnetic fields has been proposed as a possible way of increasing resolution in radio-autography1. It was reasoned that a sufficiently strong magnetic field would bend the path of emitted beta-particles into a circle of arbitrarily small radius, thereby restricting the resulting radioautographic grains to a small zone around the source. In recent reports2,3, Harford and Hamlin, using the same argument, attempted to improve the resolution of electron microscopic radioautographs by placing the specimens in a 10-kilogauss magnetic field during exposure. They could not demonstrate such an improvement; but they attributed a considerable increase in the number of exposed grains to the effect of the field on the beta-particles from tritium.

  1. Platt, J. R. , Perspectives in Biology and Medicine, 2, 24 (1958).
  2. Harford, C. G. , and Hamlin, A. , Nature, 189, 505 (1961). | Article | PubMed | ISI | ChemPort |
  3. Harford, C. G. , and Hamlin, A. , Lab. Invest., 10, 627 (1961). | PubMed | ISI | ChemPort |
  4. Johns, H. E. , and Laughlin, J. S. , in Radiation Dosimetry, edit. by Hine and Brownell (Academic Press, Inc., New York, 1956).
  5. Lea, D. E. , Actions of Radiations on Living Cells (Cambridge Univ. Press, 1956).
  6. Van Tubergen, R. P. , J. Biophys. Biochem. Cytol., 9, 219 (1961). | PubMed | ChemPort |
  7. Caro, L. G. , J. Biophys. Biochem. Cytol., 10, 37 (1961). | PubMed | ISI | ChemPort |



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