Abstract
IN conformity with the observation that only one of the three methyl groups of choline, after oxidation to betaine, can be transferred to homocysteine1, it was shown from in vivo studies2 that only the conversion of dimethylethanolamine to choline is a trans-methylation, the influence of folic acid being confined to steps leading to the formation of monomethylethanolamine and dimethylethanolamine from ethanolamine. The present in vitro experiments were carried out to ascertain, more directly, the origin of the methyl groups of choline, and their relationship to folic acid.
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DALAL, F., NORONHA, J. & SREENIVASAN, A. Biosynthesis of Choline in vitro by Rat Liver. Nature 190, 267–268 (1961). https://doi.org/10.1038/190267a0
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DOI: https://doi.org/10.1038/190267a0
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