Nature 189, 663 (25 February 1961); doi:10.1038/189663a0

Chemical Oxidation of Uridine Diphosphate-Glucose to Uridine Diphosphate-Glucuronic Acid

BERNARD JACOBSON & EUGENE A. DAVIDSON

Department of Biochemistry and Center for the Study of Aging, Duke University, Durham, North Carolina.

THE importance of uronic acids in carbohydrate metabolism has only recently begun to be elucidated. The metabolism of inositol and ascorbate is known to involve uronic acid intermediates^1,2, and nucleotide-bound glucuronic acid has been implicated in hyaluronic acid synthesis³.

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