Nature 187, 1129 (24 September 1960); doi:10.1038/1871129a0

A Transplantable Spontaneous Osteogenic Sarcoma observed in the Muscle Tissue of an Albino Mouse

R. G. HERNE, M. GREGOIRE & G. RONA

Ayerst Research Laboratories, Montreal.

OSTEOGENIC sarcomas attached to bone tissue have been reported in animals of different species. In 1936, Brues¹ described a case of spontaneous osteogenic sarcoma in the jaw of a three-year-old grey rabbit. Barrett et al. reported an osteogenic sarcoma attached to the left femur of a C3H female mouse². Osteogenic sarcomas have also been induced by radio-isotopes such as radium-226, strontium-90, calcium-45 (ref. 3) and strontium-89 (ref. 4). One case of osteogenic neoplasm arising from muscle tissue has been reported in man⁵. This tumour found in the thigh muscle had developed over a period of ten years and was believed to have followed an abscess in the muscle.

1. Brues, A. M. , Amer. J. Cancer, 28, 587 (1936).
2. Barrett, M. K. , Dalton, A. J. , Edwards, J. E. , and Greenstein, J. P. , J. Nat. Cancer Inst., 4, 389 (1943–44).
3. Finkel, M. P. , and Biskis, B. O. , Unio Int. Contr. Cancer, 15, 99 (1959). | ChemPort |
4. Skoryna, S. C. , and Kahn, D. S. , Cancer, 12, 306 (1959). | PubMed | ISI | ChemPort |
5. Vasilescu, C. , Hristu, C. , and Ivanitescu, G. , Bull. et mem. Soc. med. d. hop. de Bucaresti, 17, 174 (1935).