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Letters to Nature
Nature 186, 556 (14 May 1960); doi:10.1038/186556a0

Biosynthesis of Colchicine

A. I. SCOTT

Chemistry Department, The University, Glasgow, W.2.

OF several proposals1–4 concerning the biogenesis of the alkaloid colchicine (5; R 1 = R 2 = Me), only that of Wenkert4 involves the intervention of an intact tropolone ring prior to formation of ring B.

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References
1. Erdtman, H., and Wachtmeister, C. A., in "Festschrift Arthur Stoll", 144 (Basel, 1957). | ChemPort |
2. Belleau, B., Experientia, 9, 178 (1953). | Article | PubMed | ChemPort |
3. Anet, F. A. L., quoted by Sir R. Robinson, Proc. Roy. Soc., A, 206, 16 (1951).
4. Wenkert, E., Experientia, 15, 165 (1959). | Article | ISI | ChemPort |
5. Nozoe, T., in Fortschritte Chem. Organ. Naturstoffe, 13, 232 (1956). | ChemPort |
6. Bellet, P., Amiard, G., Pesez, M., and Petit, A., Ann. pharm. Franc., 10, 241 (1952). | PubMed | ChemPort |
7. Scaronantavý, F., and Reichstein, T., Helv. Chim. Acta, 33, 1606 (1950), and later papers.
8. Bentley, R., Biochim. Biophys. Acta, 29, 666 (1958). | Article | PubMed | ISI | ChemPort |
9. Pauson, P. L., Chem. Rev., 55, 9 (1955). | Article | ISI | ChemPort |
10. Critchlow, A., Haworth, R. D., and Pauson, P. L., J. Chem. Soc., 1318 (1951). | Article | ChemPort |



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