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Letters to Nature
Nature 184, 291 - 292 (25 July 1959); doi:10.1038/184291a0

Effect of Bacillus Calmette-Guérin Infection on Transplanted Tumours in the Mouse

LLOYD J. OLD, DONALD A. CLARKE & BARUJ BENACERRAF

Sloan-Kettering Inst., Sloan-Kettering Div., Cornell University Medical School, New York.
Department of Pathology, New York University College of Medicine, New York.

DURING the growth of certain transplanted tumours considerable hyperactivity of the reticulo-endothelial system is observed.1 Similar alterations are also found in the first stage of experimental infections2, suggesting that the host response to foreign tissue and some infectious agents is closely related. Agents such as endotoxins, zymosan, products of the tubercle bacillus, and Bacillus Calmette-Guérin infection which enhance the activity of the reticulo-endothelial system3 and the capacity for antibody production4 also increase natural resistance to infection5. In light of these observations, we have attempted to alter the growth and lethality of various experimental tumours by agents known to possess the common property of stimulating the phagocytic capacity of the reticulo-endothelial system. One such agent, zymosan, has been demonstrated to increase significantly the regression rate of the mouse tumour, sarcoma 180 (S-180), under certain conditions6. The present report deals with the course of three transplantable tumours, S-180, carcinoma 755 (Ca 755), and Ehrlich ascites, in mice infected with Bacillus Calmette-Guérin.

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  2. Biozzi, G. , Halpern, B. N. , Benacerraf, B. , and Stiffel, C. , "Physiopathology of the Reticulo-Endothelial System", 204 (Blackwells Scientific Publications, Oxford, 1957). Boehme, D. , and Dubos, R. J. , J. Exp. Med., 107, 523 (1958).
  3. Biozzi, G. , Benacerraf, B. , and Halpern, B. N. , Brit. J. Exp. Path., 36, 226 (1955). Benacerraf, B. , and Sebestyen, M. , Fed. Proc., 16, 860 (1957). Biozzi, G. , Benacerraf, B. , Grumbach, F. , Halpern, B. N. , Levaditi, J. , and Rist, N. , Ann. Inst. Pasteur, 87, 291 (1954). | PubMed | ISI | ChemPort |
  4. Johnson, A. G. , Gaines, S. , and Landy, M. , J. Exp. Med., 103, 225 (1956). Cutler, J. L. , Fed. Proc., 18, 33 (1959). Halpern, B. N. , Biozzi, G. , Stiffel, C. , and Mouton, D. , C. R. Soc. Biol., 151, 758 (1958). | Article | PubMed | ISI | ChemPort |
  5. Rowley, D. , Lancet, i, 232 (1955). Dubos, R. J. , and Schaedler, R. , J. Exp. Med., 106, 703 (1957).
  6. Bradner, W. T. , Clarke, D. A. , and Stock, C. C. , Cancer Res., 18, 347 (1958). | PubMed | ISI | ChemPort |



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