Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Aneuploid Deoxyribonucleic Acid Content of Human Carcinomas

Nature volume 184, pages 290–291 (1959)Cite this article

Abstract

THE basic question of whether primary human malignant tumours consist of euploid or aneuploid cells has so far remained unanswered. It has been possible to determine the chromosome complement and deoxyribonucleic acid content only of human carcinomas with cells exfoliated in ascitic fluid1,2, human carcinomas transplanted in rats and hamsters3 and carcinomas grown in tissue culture.4,5 This lack of information can be attributed to several technical difficulties. Chromosome counts on solid human tumours cannot be generally obtained since a pretreatment with colchicine is impossible. The deoxy ribonucleic acid measurement by the one-wave-length method has so far been limited to interphase nuclei6 in which the occurrence of deoxyribonucleic acid synthesis prevents any conclusions in regard to euploidy or aneuploidy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ising, V., and Levan, A., Acta, path. microbiol. Scand., 40, 13 (1957).

    CAS  Google Scholar 

  2. Hansen-Melander, E., Kullander, S., and Melander, Y., J. Nat. Cancer Inst., 16, 1067 (1956).

    CAS  PubMed  Google Scholar 

  3. Levan, A., Cancer, 9, 648 (1956).

    Article  CAS  Google Scholar 

  4. Hsu, T. C., J. Nat. Cancer Inst., 14, 905 (1954).

    CAS  PubMed  Google Scholar 

  5. Hsu, T. C., in Developmental Cytology, ed. D. Rudnick (The Ronald Press, New York, 1959).

    Google Scholar 

  6. Leuchtenberger, C., Leuchtenberger, R., and Davis, A., Amer. J. Path., 30, 65 (1954).

    CAS  PubMed  Google Scholar 

  7. Patau, K., Chromosoma, 5, 341 (1952).

    Article  CAS  Google Scholar 

  8. Bader, S., J. Biophys. Biochem. Cytology, 5, 217 (1959).

    Article  CAS  Google Scholar 

  9. Stich, H. F., Florian, S. F., and Emson, H. E., Proc. Amer. Assoc. Cancer Res., 3, 67 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Saskatchewan Research Unit of the National Cancer Institute of Canada, and Department of Cancer Research, University of Saskatchewan,

    H. F. STICH

  2. Department of Pathology, University Hospital, University of Saskatchewan, Saskatoon, Sask

    H. E. EMSON

Authors
  1. H. F. STICH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. E. EMSON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

STICH, H., EMSON, H. Aneuploid Deoxyribonucleic Acid Content of Human Carcinomas. Nature 184, 290–291 (1959). https://doi.org/10.1038/184290a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/184290a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing