Nature 183, 1474 - 1475 (23 May 1959); doi:10.1038/1831474a0

Labelling of Radiographic Contrast Media with Iodine-131

J. LIEBSTER, J. KÁCL & A. BABICKÝ

Radioisotopo Laboratories, Biological Institute, Czechoslovak Academy of Science and Radiological Clinic of the University, Prague. March 3.

THE rapid development and general acceptance of contrast media represents one of the outstanding successes of diagnostic röntgenology. Roentgen contrast media are generally di- or tri-iodo derivatives of benzene or pyridine, containing further substituents influencing solubility. The most widely used contrast compounds are 3,5-diiodo-4-pyridon-N-acetic acid as its diethanolamine salt ('Iodopyracet', 'Diodrast', 'Diodone', 'Ioduron', etc.), and N-methyl-3,5-diiodo-chelidamate as its disodium salt ('Neo-Iopax', 'Iodoxyl', 'Uropac', etc.). A new compound of the urotropic class is sodium-3-acetyl-amino-2,4,6-tri-iodobenzoate known as 'Triopac', 'Urokon', 'Triumbren' and diacetylamino-2,4,6-triiodobenzoic acid, the methylglucamate of which is known as 'Urografin'. The hepatotropic contrast media are represented by N,N'-adipyl-bis(3-amino-2,4,6-triiodo)-benzoic acid as methylglucamate ('Biligrafin' or 'Cholografin') and 2-ethyl-3-(3'-amino-2,4,6-triiodophenyl)-propionic acid ('Cistobil', 'Telepaque').