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Letters to Nature
Nature 181, 906-907 (29 March 1958) | doi:10.1038/181906b0
Uridine Diphosphate Amino-sugar Compounds from Staphylococcus aureus inhibited by Penicillin
EIJI ITO, NOBUTOSHI ISHIMOTO & MASAHIRO SAITO
- Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Japan. Sept. 13.
Abstract
IN 1952, Park1 showed that three uridine diphos-phate amino-sugar compounds were accumulated in Staphylococcus aureus inhibited by penicillin. Compound I contained no amino-acid residue. Compound II contained one alanine residue and compound III contained a peptide which was composed of one glutamic acid, one lysine and three alanine residues. Recently, Strominger indicated that, even though in much smaller amount, these compounds are contained also in normal cells2, and that the amino-sugar component is 3-O-carboxyethyl glucosamine3, which is known as one of the main components of cell walls4.
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