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Sensitivity of Immature Mouse Sperm to the Mutagenic Effects of X-Rays

Abstract

WE consider that Dr. Bateman's timing of spermatogenic events in the mouse1 requires discussion because of the impact it bears on the interpretation of radiation sensitivities. We believe that his estimate of six to seven weeks between spermatocytes and ejaculation, based on genetical evidence, shows a serious discrepancy with other estimates based on non-genetical evidence. The following non-genetical evidence is taken from work on the seminiferous epithelium dealing with, first, the relative frequency of cell associations in normal males; secondly, these associations and their timing in irradiated males; thirdly, its labelling with radioactive tracers; and fourthly, the pattern of damage after various doses of radiation.

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SIRLIN, J., EDWARDS, R. Sensitivity of Immature Mouse Sperm to the Mutagenic Effects of X-Rays. Nature 179, 725–727 (1957). https://doi.org/10.1038/179725b0

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