Abstract
WE consider that Dr. Bateman's timing of spermatogenic events in the mouse1 requires discussion because of the impact it bears on the interpretation of radiation sensitivities. We believe that his estimate of six to seven weeks between spermatocytes and ejaculation, based on genetical evidence, shows a serious discrepancy with other estimates based on non-genetical evidence. The following non-genetical evidence is taken from work on the seminiferous epithelium dealing with, first, the relative frequency of cell associations in normal males; secondly, these associations and their timing in irradiated males; thirdly, its labelling with radioactive tracers; and fourthly, the pattern of damage after various doses of radiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bateman, A. J., Nature, 178, 1278 (1956).
Roosen-Runge, E. C., and Giesel, L. O., Amer. J. Anat., 87, 1 (1950).
Leblond, C. P., and Clermont, Y., Amer. J. Anat., 90, 167 (1952).
Oakberg, E. F., Radiation Research, 2, 369 (1955); J. Morph., 97, 39 (1955).
Oakberg, E. F., Amer. J. Anat. (abst., in the press).
Sirlin, J. L., and Edwards, R. G., Exp. Cell Res., 9, 596 (1955).
Pelc, S. R., and Howard, A., Exp. Cell Res., 11, 128 (1956).
Glücksmann, A., Howard, A., and Pelc, S. R., J. Anat., 89, 13 (1955).
Swift, H. H., Physiol. Zool., 23, 169 (1950).
Hertwig, P., Biol. Z., 58, 273 (1938).
Clermont, Y., and Leblond, C. P., Amer. J. Anat., 93, 475 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SIRLIN, J., EDWARDS, R. Sensitivity of Immature Mouse Sperm to the Mutagenic Effects of X-Rays. Nature 179, 725–727 (1957). https://doi.org/10.1038/179725b0
Issue Date:
DOI: https://doi.org/10.1038/179725b0
This article is cited by
-
Does caffeine induce dominant lethal mutations in mice?
Human Genetics (1969)
-
Dominant lethal mutations induced in male mice by methyl methanesulphonate
Heredity (1964)
-
The sensitivity of the male germ cells of Drosophila to methyl methanesulphonate
Heredity (1964)
-
Sensitivity of the Spermatogenic Process in the Rat to Radiomimetic Drugs and X-Rays
Nature (1958)
-
Mutagenic sensitivity of maturing germ cells in the male mouse
Heredity (1958)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.