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| Nature 177, 480 (10 March 1956); doi:10.1038/177480a0 |
|
Mode of Action of Isonicotinic Hydrazide
S. D. RUBBO, JANICE EDGAR, J. CYMERMAN-CRAIG, G. N. VAUGHAN & D. WILLIS
School of Bacteriology, University of Melbourne.
Department of Organic Chemistry, University of Sydney. Nov. 4.
IN our earlier report we directed attention to the importance of chelation as an essential step in the anti-tuberculous activity of isonicotinic hydrazide (isoniazid)1. It was impossible to decide whether the chelating action with a metal or metals took place before (in the medium) or after adsorption on the bacterial cell.
- Cymerman-Craig , Rubbo , Willis and Edgar , Nature, 176, 34 (1955). | Article | PubMed | ChemPort |
- Rubbo , Albert and Gibson , Brit. J. Exp. Path., 31, 425 (1950). | PubMed | ISI | ChemPort |
- Rubbo and Pierson , Amer. Rev. Tuberc., 68, 48 (1953). | ISI | ChemPort |
- Rubbo and Cymerman-Craig , Nature, 176, 887 (1955). | PubMed | ISI | ChemPort |
- Cymerman-Craig , Rubbo and Pierson , Brit. J. Exp. Path., 35, 478 (1954). | PubMed | ChemPort |
© 1956 Nature Publishing Group
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