Nature 176, 563 (17 September 1955); doi:10.1038/176563a0

Lowered 'Capillary Resistance' after Iontophoresis of Lysergic Acid Diethylamide

E. L. BLAIR, MAVIS WAKEFIELD, G. I. C. INGRAM & P. ABMITAGE

Department of Medicine, Department of Surgery, University of Edinburgh.
Statistical Research Unit of the Medical Research Council. May 30.

THERE is some evidence that 5-hydroxytryptamine may be concerned in hæmostasis (reviewed by Page¹); but it is difficult to test directly the hæmostatic effect of the drug in normal persons, because, if it has such a role, it is presumably already available in optimal concentration. An attempt was therefore made to weaken the normal hæmostatic system in man by treatment with lysergic acid diethylamide, which Gaddum, Hameed, Hathway and Stephens² have found to be a potent inhibitor of 5-hydroxytryptamine on the isolated rat uterus. Because of its effect on the personality, the drug could not be administered systemically. The effect of the drug was therefore investigated by measuring the 'capillary resistance' in small areas of skin which had been infiltrated by iontophoresis.

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2. Gaddum, J. H. , Hameed, K. A. , Hathway, D. E. , and Stephens, F. F. , Quart. J. Exp. Physiol., 40, 49 (1955). | PubMed | ChemPort |
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