Nature 175, 208 - 209 (29 January 1955); doi:10.1038/175208a0

Rat Liver Xanthine Oxidase in Carbon Tetrachloride Poisoning

GILBERTO G. VILLELA & EMILIO MITIDIERI

Division of Biochemistry, Oswaldo Cruz Institute, Rio de Janeiro. Sept. 24.

DURING the course of experiments dealing with the effect of some hepatotoxic drugs on rat liver xanthine oxidase, it was found that this enzyme is activated when carbon tetrachloride is administered in a single necrogenic dosage. The present communication presents results obtained in normal young rats injected subcutaneously with 0.1 ml./100 gm. body-weight.

1. Axelrod, A. E. , and Elvehjem, C. A. , J. Biol. Chem., 140, 725 (1941). | ChemPort |
2. Dhungat, S. B. , and Sreenivasan, A. , J. Biol. Chem., 208, 845 (1954). | PubMed | ISI | ChemPort |
3. Dixon, M. , and Elliott, K. A. C. , Biochem. J., 28, 812 (1929).
4. Villela, G. G. , Rev. Bras. Biol., [14, 455 (1954)]. | ChemPort |
5. Litwak, J. W. , Bothwell, J. W. , Williams, jun., J. N. , and Elvehjem, C. A. , J. Biol. Chem., 200, 303 (1953). | PubMed | ISI | ChemPort |
6. Forbes, J. C. , and Neale, R. C. , Proc. Soc. Exp. Biol. Med., 34, 319 (1936).
7. Popper, H. , Koch-Weser, D. , and Szanto, P. B. , Proc. Soc. Exp. Biol. Med., 71, 688 (1949). | ISI | ChemPort |