Abstract
SYNTHESES of α-alkyl- or α,α′-dialkyl-4,4′-stilbenediols and of their derivatives, several of which exhibit remarkable œstrogenic activity, have so far mostly been by demethylation of the corresponding dimethyl ethers, and have invariably involved several stages1,2. A direct synthesis in one step, of trans-α-methyl-4,4′-stilbenediol (and some of its dialkyl ethers) from phenol (or its corresponding ether) and chloroacetone, has now been accomplished.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
See, inter alia, Dodds, E. C., Golberg, L., Lawson, W., and Robinson, R., Nature, 141, 247 (1938). Kuwada, S., and Sasagawa, Y., J. Pharm. Soc. Japan, 60, 93 (1940). Kuwada, S., Sasagawa, Y., and Nisikawa, M., ibid., 60, 553 (1940). Vargha, L. v., and Kovács, E., Ber., 75, B, 794 (1942). Kharasch, M. S., and Kleiman, M., J. Amer. Chem. Soc., 65, 11 (1943). Wilds, A. L., and Bigger-staff, W. R., ibid., 67, 789 (1945). Shishido, K., and Nozaki, H., ibid., 70, 776 (1948).
Dodds, E. C., Golberg, L., Grünfeld, E. I., Lawson, W., Saffer, C. M., jun., and Robinson, R., Proc. Roy. Soc., B, 132, 83 (1944).
Lippmann, E., Ber., 45, 2489 (1912).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BHARGAVA, P., ZAHEER, S. A New Synthesis of some Derivatives of 4,4′-Stilbenediol. Nature 171, 746–747 (1953). https://doi.org/10.1038/171746b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/171746b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
