Nature 167, 447 - 448 (17 March 1951); doi:10.1038/167447b0

Terramycin and Spironema duttoni Infections

G. BERKS & L. G. GOODWIN

Wellcome Laboratories of Tropical Medicine, 183–193 Euston Road, London, N.W.1. Dec. 13.

IN the course of experiments with terramycin upon various laboratory infections, we have found that the drug has a powerful effect on Spironema duttoni in mice. The animals were inoculated intraperitoneally with a suspension of blood from a heavily infected mouse. Untreated mice usually died in three to six days; occasionally a mouse survived and the infection pursued a relapsing course. Treatment with terramycin was given on the day after infection, either by subcutaneous injection or by stomach tube.