Abstract
THE occurrence of a new strain of mice (Mus musculus, L.) resembling the extinct souris luxées of Rabaud1 has been reported2 ; these mice show extensive abnormalities of the hind limbs, including absence of the tibia (hemimelia). The condition was found to be due to the presence in homozygous form of a single mutant gene which was called 'luxate', symbol lx. This has been found to be in the linkage group designated as the third by Dunn, Grüneberg and Snell8, closely linked to macrocytic anæmia, Wv 4. The other markers known to be in this group are recessive spotting, s, hairlessness, hr 6, and pirouette, pi 6; s, hr and Wv are known to lie in that order7.
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References
Rabaud, E., C.R. Soc. Biol., 77, 411 (1914).
Carter, T. C., Heredity, 2, 405 (1947) (abstract).
Dunn, L. C., Grüneberg, H., and Snell, G. D., J. Hered., 31, 505 (1940).
Little, C. C., and Cloudman, A. M., Proc. U.S. Nat. Acad. Sci., 23, 535 (1937).
Snell, G. D., Genetics, 16, 42 (1931).
Dickie, M. M., and Woolley, G. W., J. Hered., 37, 335 (1948).
Gates, W. H., and Pullig, T., Proc. La. Acad. Sci., 9, 57 (1945).
Fisher, R. A., Amer. Nat., 80, 568 (1946).
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CARTER, T. Position of 'Luxate' in the Third Linkage Group of the House Mouse. Nature 164, 1138 (1949). https://doi.org/10.1038/1641138b0
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DOI: https://doi.org/10.1038/1641138b0
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