Abstract
ALTHOUGH much attention has been given to the importance of prosthetic groups of certain enzymes for their activity, the part played by the protein portion of the molecule is still little understood. For example, how far a modification in the protein portion of an enzyme molecule without affecting its prosthetic group would be reflected in its enzymic and other properties is scarcely known. For the study of this problem the extremely stable protein cytoehrome c seems most suitable. In the following experiments, cytochrome c was modified by splitting off a great part of the protein portion of the molecule with pepsin. The resulting substance was then isolated and studied.
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Tsou, C. Cytochrome c Modified by Digestion with Pepsin. Nature 164, 1134–1135 (1949). https://doi.org/10.1038/1641134a0
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DOI: https://doi.org/10.1038/1641134a0
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