Abstract
THE mealworm, Tenebrio molitor, has recently been shown to be a very suitable test subject for folic acid and certain other, still unidentified B-factors. When grown on an artificial diet consisting of casein (20 parts), glucose (80 parts), water-insoluble fraction from yeast (2·5 parts), cholesterol (1 part), a salt mixture (2 parts), and aneurin, ribo-flavin, nicotinic acid, pyridoxin, pantothenic acid, choline chloride and inositol in ample amounts, at least two more factors are essential for growth and survival, folic acid and a factor contained in a norite filtrate from yeast or liver extract1,2. In view of the present interest in the folic acid group and its relation to anti-anaemia principles, our recent results on the mealworm may be of general interest. Throughout this report the term folic acid has been used to denote pteroylglutamie acid.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fraenkel, G., and Blewett, M., Nature, 157, 697 (1946).
Fraenkel, G., and Blewett, M., Biochem. J., 41, 469 (1947).
Welch, A. D., Heinle, R. W., Nelson, E. M., and Nelson, H. V., J. Biol. Chem., 164, 787 (1946).
Jukes, T. H., and Stokstad, E. L. R., J. Biol. Chem., 168, 563 (1947).
Clark, G. W., Amer. J. Med. Sci., 209, 520 (1945).
Stokstad, E. L. R., and Jukes, T. H., Proc. Soc. Exp. Biol. Med., 62, 112 (1946).
Pfiffner, J. J., Binkley, S. B., Bloom, E. S., and O‘Dell, B. L., J. Amer. Chem. Soc., 69, 1476 (1947).
Golberg, L., De Meillon, B., and Murray, J. F., Nature, 160, 22 (1947).
Jaffé, W. G., and Elvehjem, C. A., J. Biol. Chem., 169, 287 (1947).
Woolley, D. W., and Sprince, H., J. Biol. Chem., 157, 447 (1945).
Schumacher, A. E., Heuser, G. F., and Norris, L. C., J. Biol. Chem., 154, 713 (1940).
Hill, F. W., Thesis, Cornell University, 1944 (quoted from Scott et al., 1946)23.
Charkey, L. W., Thesis, Cornell University, 1945 (quoted from Scott et al., 1946)23.
Scott, M. L., Norris, L. C., and Heuser, G. F., J. Biol. Chem., 167, 261 (1947).
Cooperman, J. M., Elvehjem, C. A., McCall, K. B., and Ruegamer, W. R., Proc. Soc. Exp. Biol. Med., 61, 92 (1946).
Cooperman, J. M., Ruegamer, W. R., Sneell, E. E., and Elvehjem, C. A., J. Biol. Chem., 163, 769 (1946).
Luckey, T. D., Moore, P. R., Elvehjem, C. A., and Hart, E. B., Proc. Soc. Exp. Biol. Med., 62, 307 (1946).
Petering, H. G., Marvel, J. P., Glausier, C. E., Jr., and Waddell, L., J. Biol. Chem., 162, 477 (1946).
Wills, L., Proc. Nutrition Soc., 4, 140 (1946).
Scott, M. L., Norris, L. C., Heuser, G. F., and Bruce, W. F., J. Biol. Chem., 158, 291 (1945).
Hutchings, B. L., Oleson, J. J., and Stokstad, E. L. R., J. Biol. Chem., 163, 447 (1946).
Campbell, C. J., Brown, R. A., Bird, O. D., and Emmet, A. D., J. Nutrition, 32, 423 (1946).
Scott, M. L., Norris, L. C., Charkey, L. W., Daniel, L. J., and Heuser, G. F., J. Biol. Chem., 164, 403 (1946).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FRAENKEL, G., BLEWETT, M. & COLES, M. BT, A New Vitamin of the B-Group and its Relation to the Folic Acid Group, and Other Anti-AnÆmia Factors. Nature 161, 981–983 (1948). https://doi.org/10.1038/161981a0
Issue Date:
DOI: https://doi.org/10.1038/161981a0
This article is cited by
-
Carnitine in human nutrition
Zeitschrift für Ernährungswissenschaft (1982)
-
Specific vitamin requirements of insect cell lines (P. Americana) according to their tissue origin and in vitro conditions
In Vitro (1981)
-
Synthesis of vitamin BT (DL-carnitine hydrochloride)
Pharmaceutical Chemistry Journal (1968)
-
Carnitine (Vitamin BT) as a Nutritional Requirement for the Confused Flour Beetle
Nature (1954)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
