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Nature 158, 558 (19 October 1946) | doi:10.1038/158558a0;

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Gene Recombination in Escherichia Coli

JOSHUA LEDERBERG & E. L. TATUM

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The mutants consist of strains which differ from their parent wild type, strain JKM2, in lacking the ability to synthesize growth-factors. As a result of these deficiencies they will only grow in media supplemented with their specific nutritional requirements.