Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Mode of Action of Benzylamine Sulphonamide ('Marfanil')

Abstract

THE antibacterial agent benzylamine-4-sulphon-amide (I), which under the name of 'Marfanil' was supplied in quantity to Rommel's forces in North Africa, has given interesting results in Allied hands (cf. Mitchell, Rees and Robinson1). Organisms made resistant to sulphanilamide by growing them in contact with the drug were resistant to all other sulphonamides except 'Marfanil'2. Schreuss found that the antibacterial action of 'Marfanil' was not antagonized by p-aminobenzoic acid3. A possible reason for these differences from the sulphanilamide-like drugs is revealed by the determination of the basic strength.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mitchell, G., Rees, W., and Robinson, C., Lancet, 627 (1944).

  2. Selbie, F., and McIntosh, J., Brit. J. Exper. Path., 24, 246 (1943).

    Google Scholar 

  3. Schreuss, H., Klin. Wochsch., 21, 671 (1942).

    Article  Google Scholar 

  4. Albert, A., and Goldacre, R., Nature, 149, 245 (1942).

    Article  ADS  CAS  Google Scholar 

  5. Bell, P., and Roblin, R., J. Amer. Chem. Soc., 64, 2905 (1942).

    Article  CAS  Google Scholar 

  6. Albert, A., and Magrath, D., J. Chem. Soc., in the Press.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GOLDACRE, R. Mode of Action of Benzylamine Sulphonamide ('Marfanil'). Nature 154, 796–797 (1944). https://doi.org/10.1038/154796b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/154796b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing