Letters to Editor
nature 145, 1022-1022 (29 June 1940) | doi:10.1038/1451022a0
Cultivation of Bluetongue Virus in Fertile Eggs produced on a Vitamin-deficient Diet
J. H. MASON , J. D. W. A. COLES & R. A. ALEXANDER
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Two of us (R.A.A. and J.H.M.) have made many unsuccessful attempts to infect mice, guinea pigs, rabbits, hamsters, hedgehogs, and chicks with blue-tongue virus. Mice and guinea pigs were not rendered susceptible by blockading the reticulo-endothelial system with India ink, by deep X-ray therapy, or by maintenance on a vitamin-deficient diet of auto-claved oats. Finally no multiplication occurred in normal developing chick embryos when virus was seeded on the chorio-allantoic membrane, or in the yolk-sac (method of Cox, 1938).
