Malaria 2010 update

In this focus

Despite increasing research efforts, malaria remains a significant cause of human mortality. The discovery of new drug and vaccine leads, the implementation of effective control measures in light of a changing world and an understanding of the mechanisms underlying human–parasite and vector–parasite interactions are all required to get a step closer to the ultimate goal of eradicating this disease. In all of these areas, the past year has produced some very interesting new insights that we are proud to present in this focus.

Image: Samuel Connell and W Armand Guiguemde


Current Research


Thousands of chemical starting points for antimalarial lead identification Free access

Francisco-Javier Gamo et al.

Nature 465, 305–310 (20 May 2010) doi:10.1038/nature09107


Chemical genetics of Plasmodium falciparum Free access

W. Armand Guiguemde et al.

Nature 465, 311–315 (20 May 2010) doi:10.1038/nature09099


Climate change and the global malaria recession

Peter W. Gething et al.

Nature 465, 342–345 (20 May 2010) doi:10.1038/nature09098


Odorant reception in the malaria mosquito Anopheles gambiae

Allison F. Carey, Guirong Wang, Chih-Ying Su, Laurence J. Zwiebel & John R. Carlson

Nature 464, 66–71 (4 March 2010) doi:10.1038/nature08834

News and Views

Behavioural neurobiology: The treacherous scent of a human

Walter S. Leal

Nature 464, 37–38 (4 March 2010) doi:10.1038/464037a


Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

Ilaria Russo et al.

Nature 463, 632–636 (4 February 2010) doi:10.1038/nature08726


An aspartyl protease directs malaria effector proteins to the host cell

Justin A. Boddey et al.

Nature 463, 627–631 (4 February 2010) doi:10.1038/nature08728


Evolution of a malaria resistance gene in wild primates

Jenny Tung et al.

Nature 460, 388–391 (16 July 2009) doi:10.1038/nature08149


A newly discovered protein export machine in malaria parasites

Tania F. de Koning-Ward et al.

Nature 459, 945–949 (18 June 2009) doi:10.1038/nature08104

News and Views

Malaria: The gatekeeper revealed

Sarah B. Reiff & Boris Striepen

Nature 459, 918–919 (18 June 2009) doi:10.1038/459918a


Discovery of dual function acridones as a new antimalarial chemotype

Jane X. Kelly et al.

Nature 459, 270–273 (14 May 2009) doi:10.1038/nature07937


A global network for investigating the genomic epidemiology of malaria

The Malaria Genomic Epidemiology Network

Nature 456, 732–737 (11 December 2008) doi:10.1038/nature07632



Malaria and climate change

Listen to researcher Peter Gething as he talks to Nature about the effects of a warming climate on the incidence of malaria worldwide.