WEB FOCUS

Frontiers in HIV/AIDS

In this focus

• Current Research

Development of an effective HIV/AIDS vaccine and new drugs to treat established disease remain an urgent and pressing need. To conquer the enormous challenge demands a far better understanding of the biology of the virus, its interaction with infected cells, and the response of the immune system, than is currently at our disposal.

This web focus presents a selection of recent research papers in Nature that advance our knowledge in this regard. It also includes a Feature highlighting the expanding HIV epidemic in China, a Review article covering the challenges in vaccine development, and a Commentary calling for better communication and cooperation between vaccinologists, virologists and experts in innate anti-viral immune responses. We hope you will find it helpful.

Image: CDC/ C. Goldsmith, P. Feorino, E. L. Palmer and W. R. McManus

Current Research

Review

Challenges in the development of an HIV-1 vaccine

Dan Barouch

Nature 455, 613–619 (2 October 2008) doi:10.1038/nature07352

Full Text | PDF

Commentary

HIV immunology needs a new direction

Ruslan Medzhitov & Dan Littman

Nature 455, 591 (2 October 2008) doi:10.1038/455591a

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Feature

Changing landscape of HIV-1 infection in Yunnan, China

Lin Lu et al.

Nature 455, 609–611 (2 October 2008) doi:10.1038/455609a

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Letter

Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960

Michael Worobey et al.

Nature 455, 661–664 (2 October 2008) doi:10.1038/nature07390

Abstract | Full Text | PDF | Supplementary Information

Letter

Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease

Marius Clore, Chun Tang, John Louis, Annie Aniana & Jeong-Yong Suh

Nature 455, 693–696 (2 October 2008) doi:10.1038/nature07342

Abstract | Full Text | PDF | Supplementary Information

Letter

Molecular architecture of native HIV-1 gp120 trimers

Jun Liu, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro & Sriram Subramaniam

Nature 455, 109–113 (4 September 2008) doi:10.1038/nature07159

Abstract | Full Text | PDF | Supplementary Information

Letter

Imaging the biogenesis of individual HIV-1 virions in live cells

Nolwenn Jouvenet, Paul D. Bieniasz & Sanford M. Simon

Nature 454, 236–240 (10 July 2008) doi:10.1038/nature06998

Abstract | Full Text | PDF | Supplementary Information

Article

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

Stuart J. D. Neil, Trinity Zang & Paul D. Bieniasz

Nature 451, 425–430 (24 January 2008) doi:10.1038/nature06553

Abstract | Full Text | PDF | Supplementary Information

Article

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Tongqing Zhou et al.

Nature 445, 732–737 (15 February 2007) doi:10.1038/nature05580

Abstract | Full Text | PDF | Supplementary Information

Letter

Fc receptor but not complement binding is important in antibody protection against HIV

Ann J. Hessell et al.

Nature 449, 101–104 (6 September 2007) doi:10.1038/nature06106

Abstract | Full Text | PDF | Supplementary Information