WEB FOCUS

New horizons in cancer research

In this focus

Recent years have seen an explosion of new discoveries of the diverse molecular and biological changes underlying cancer development and progression. These insights are changing our understanding of the complex pathways that regulate cancer cell biology, the interactions of tumours with their microenvironment, and the mechanisms that normally restrain tumourigenesis. Importantly, researchers are translating these findings into novel approaches towards cancer diagnosis, prognosis and therapies.

This Nature web focus combines three News Features on the latest horizons in cancer research, newly published papers concerning the generation of cancer stem cells and the regulation of tumour angiogenesis, and a comprehensive archive of selected papers reporting important advances and trends in cancer research.

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Current Research

NEWS FEATURE

New fronts in an old war

Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442735a


NEWS FEATURE

Caught in time

Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442736a


NEWS FEATURE

The root of the problem

Alison Abbott

Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442742a


NEWS FEATURE

Off by a whisker Free access

Carina Denis

Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442739a


ARTICLE

PML inhibits Hif-1a translation and neoangiogenesis through repression of mTOR

Rosa Bernardi et al.

Nature 442, 779-785 (17 Aug 2006) doi:10.1038/nature05029


BRIEFING

Cancer: the prognosis

Helen Pearson

published online: 17 Aug 2006; doi:10.1038/060814-7


LETTER

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9

Andrei V. Krivtsov et al.

Nature 442, 818-822 (16 July 2006) doi:10.1038/nature04980


NEWS AND VIEWS

Cancer biology: A game of subversion Free access

Emmanuelle Passegué

Nature advance online publication 442,(16 July 2006) doi:10.1038/nature05085


REVIEW

The mighty mouse: genetically engineered mouse models in cancer drug development

Norman E. Sharpless and Ronald A. DePinho

Nature Reviews Drug Discovery advance online publication (18 August 2006) doi:10.1038/nrd2110


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Archive

MicroRNAs and cancer

LETTER

A microRNA polycistron as a potential human oncogene

Lin He et al.

Nature 435, 828-833 (9 June 2005) doi:10.1038/nature03552

LETTER

MicroRNA expression profiles classify human cancers

Jun Lu et al.

Nature 435, 834-838 (9 June 2005) doi:10.1038/nature03702

LETTER

c-Myc-regulated microRNAs modulate E2F1 expression

Kathryn A. O'Donnell et al.

Nature 435, 839-843 (9 June 2005) doi:10.1038/nature03677

NEWS & VIEWS

Cancer genomics: Small RNAs with big impacts

Paul S. Meltzer

Nature 435, 745-746 (9 June 2005) doi:10.1038/435745a

Mechanisms of tumour suppression and oncogenesis

LETTER

IL-23 promotes tumour incidence and growth

John L. Langowski et al.

Nature 442, 461-465 (27 July 2006) doi:10.1038/nature04808; Received 22 November 2005; Accepted 11 April 2006; Published online 10 May 2006

LETTER

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

Byung-Gyu Kim et al.

Nature 441, 1015-1019 (22 June 2006) doi:10.1038/nature04846; Received 9 February 2006; Accepted 28 April 2006

LETTER

Identification of a tumour suppressor network opposing nuclear Akt function

Lloyd C. Trotman et al.

Nature 441, 523-527 (25 May 2006) doi:10.1038/nature04809; Received 15 February 2006; Accepted 13 April 2006; Published online 7 May 2006

ARTICLE

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jirina Bartkova et al.

Nature 434, 864-870 (14 April 2005) doi:10.1038/nature03482;

LETTER

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Vassilis G. Gorgoulis et al.

Nature 434, 907-913 (14 April 2005) doi:10.1038/nature03485;

NEWS & VIEWS

Medicine: Aborting the birth of cancer

Ashok R. Venkitaraman

Nature 434, 829-830 (14 April 2005) doi:10.1038/434829a;

ARTICLE

Oncogene-induced senescence as an initial barrier in lymphoma development

Melanie Braig et al.

Nature 436, 660-665 (4 August 2005) doi:10.1038/nature03841;

LETTER

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou et al.

Nature 436, 720-724 (4 August 2005) doi:10.1038/nature03890;

LETTER

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen et al.

Nature 436, 725-730 (4 August 2005) doi:10.1038/nature03918; Received 23 February 2005; Accepted 15 June 2005

BRIEF COMMUNICATION

Tumour biology: Senescence in premalignant tumours

Manuel Collado et al.

Nature 436, 642 (4 August 2005) doi:10.1038/436642a;

NEWS & VIEWS

Cancer: Crime and punishment

Norman E. Sharpless et al.

Nature 436, 636-637 (4 August 2005) doi:10.1038/436636a;

ARTICLE

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

Michael T. Hemann et al.

Nature 436, 807-811 (11 August 2005) doi:10.1038/nature03845;

NEWS & VIEWS

Cancer: Two in one

Anton Berns

Nature 436, 787-789 (11 August 2005) doi:10.1038/436787a;

Metastases

ARTICLE

Genes that mediate breast cancer metastasis to lung

Andy J. Minn et al.

Nature 436, 518-524 (28 July 2005) doi:10.1038/nature03799;

ARTICLE

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Rosandra N. Kaplan et al.

Nature 438, 820-827 (8 December 2005) doi:10.1038/nature04186;

LETTER

A microRNA polycistron as a potential human oncogene

Lin He et al.

Nature 435, 828-833 (9 June 2005) doi:10.1038/nature03552

Cancer therapy and therapeutic targets

LETTER

A loss-of-function RNA interference screen for molecular targets in cancer

Vu N. Ngo et al.

Nature 441, 106-110 (4 May 2006) doi:10.1038/nature04687; Received 5 December 2005; Accepted 2 March 2006; Published online 29 March 2006

NEWS & VIEWS

Cell biology: Divining cancer cell weaknesses

William G. Kaelin

Nature 441, 32-34 (4 May 2006) doi:10.1038/441032a;

LETTER

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Andrea H. Bild et al.

Nature 439, 353-357 (19 January 2006) doi:10.1038/nature04296;

LETTER

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit et al.

Nature 439, 358-362 (19 January 2006) doi:10.1038/nature04304;

NEWS & VIEWS

Cancer biology: Signatures guide drug choice

Julian Downward

Nature 439, 274-275 (19 January 2006) doi:10.1038/439274a;

LETTER

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer et al.

Nature 434, 917-921 (14 April 2005) doi:10.1038/nature03445;

LETTER

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant et al.

Nature 434, 913-917 (14 April 2005) doi:10.1038/nature03443;

LETTER

Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system

Shiladitya Sengupta et al.

Nature 436, 568-572 (28 July 2005) doi:10.1038/nature03794;

NEWS & VIEWS

Cancer: One step at a time

David Mooney

Nature 436, 468-469 (28 July 2005) doi:10.1038/436468a;