WEB FOCUS
New horizons in cancer research
In this focus
Recent years have seen an explosion of new discoveries of the diverse molecular and biological changes underlying cancer development and progression. These insights are changing our understanding of the complex pathways that regulate cancer cell biology, the interactions of tumours with their microenvironment, and the mechanisms that normally restrain tumourigenesis. Importantly, researchers are translating these findings into novel approaches towards cancer diagnosis, prognosis and therapies.
This Nature web focus combines three News Features on the latest horizons in cancer research, newly published papers concerning the generation of cancer stem cells and the regulation of tumour angiogenesis, and a comprehensive archive of selected papers reporting important advances and trends in cancer research.
Current Research
NEWS FEATURE
New fronts in an old war
Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442735a
NEWS FEATURE
Caught in time
Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442736a
NEWS FEATURE
The root of the problem
Alison Abbott
Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442742a
NEWS FEATURE
Off by a whisker Free access
Carina Denis
Nature 442, 164-171 (17 Aug 2006) doi:10.1038/442739a
ARTICLE
PML inhibits Hif-1a translation and neoangiogenesis through repression of mTOR
Rosa Bernardi et al.
Nature 442, 779-785 (17 Aug 2006) doi:10.1038/nature05029
Abstract | Full Text | PDF | Supplementary Information
BRIEFING
Cancer: the prognosis
Helen Pearson
published online: 17 Aug 2006; doi:10.1038/060814-7
LETTER
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
Andrei V. Krivtsov et al.
Nature 442, 818-822 (16 July 2006) doi:10.1038/nature04980
Abstract | Full Text | PDF | Supplementary Information
NEWS AND VIEWS
Cancer biology: A game of subversion Free access
Emmanuelle Passegué
Nature advance online publication 442,(16 July 2006) doi:10.1038/nature05085
REVIEW
The mighty mouse: genetically engineered mouse models in cancer drug development
Norman E. Sharpless and Ronald A. DePinho
Nature Reviews Drug Discovery advance online publication (18 August 2006) doi:10.1038/nrd2110
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Links
- Milestones in cancer
- Cancer subject area
- Insight: Signalling in cancer
- British Journal of Cancer
- Cancer Gene Therapy
- Nature Cell Biology
- NCP Oncology
- Nature Reviews Cancer
- Oncogene
Archive
MicroRNAs and cancer
LETTER
A microRNA polycistron as a potential human oncogene
Lin He et al.
Nature 435, 828-833 (9 June 2005) doi:10.1038/nature03552
Abstract | Full Text | PDF | Supplementary Information
LETTER
MicroRNA expression profiles classify human cancers
Jun Lu et al.
Nature 435, 834-838 (9 June 2005) doi:10.1038/nature03702
Abstract | Full Text | PDF | Supplementary Information
LETTER
c-Myc-regulated microRNAs modulate E2F1 expression
Kathryn A. O'Donnell et al.
Nature 435, 839-843 (9 June 2005) doi:10.1038/nature03677
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cancer genomics: Small RNAs with big impacts
Paul S. Meltzer
Nature 435, 745-746 (9 June 2005) doi:10.1038/435745a
Mechanisms of tumour suppression and oncogenesis
LETTER
IL-23 promotes tumour incidence and growth
John L. Langowski et al.
Nature 442, 461-465 (27 July 2006) doi:10.1038/nature04808; Received 22 November 2005; Accepted 11 April 2006; Published online 10 May 2006
Abstract | Full Text | PDF | Supplementary Information
LETTER
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
Byung-Gyu Kim et al.
Nature 441, 1015-1019 (22 June 2006) doi:10.1038/nature04846; Received 9 February 2006; Accepted 28 April 2006
Abstract | Full Text | PDF | Supplementary Information
LETTER
Identification of a tumour suppressor network opposing nuclear Akt function
Lloyd C. Trotman et al.
Nature 441, 523-527 (25 May 2006) doi:10.1038/nature04809; Received 15 February 2006; Accepted 13 April 2006; Published online 7 May 2006
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova et al.
Nature 434, 864-870 (14 April 2005) doi:10.1038/nature03482;
Abstract | Full Text | PDF | Supplementary Information
LETTER
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
Vassilis G. Gorgoulis et al.
Nature 434, 907-913 (14 April 2005) doi:10.1038/nature03485;
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Medicine: Aborting the birth of cancer
Ashok R. Venkitaraman
Nature 434, 829-830 (14 April 2005) doi:10.1038/434829a;
ARTICLE
Oncogene-induced senescence as an initial barrier in lymphoma development
Melanie Braig et al.
Nature 436, 660-665 (4 August 2005) doi:10.1038/nature03841;
Abstract | Full Text | PDF | Supplementary Information
LETTER
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Chrysiis Michaloglou et al.
Nature 436, 720-724 (4 August 2005) doi:10.1038/nature03890;
Abstract | Full Text | PDF | Supplementary Information
LETTER
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Zhenbang Chen et al.
Nature 436, 725-730 (4 August 2005) doi:10.1038/nature03918; Received 23 February 2005; Accepted 15 June 2005
Abstract | Full Text | PDF | Supplementary Information
BRIEF COMMUNICATION
Tumour biology: Senescence in premalignant tumours
Manuel Collado et al.
Nature 436, 642 (4 August 2005) doi:10.1038/436642a;
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cancer: Crime and punishment
Norman E. Sharpless et al.
Nature 436, 636-637 (4 August 2005) doi:10.1038/436636a;
ARTICLE
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
Michael T. Hemann et al.
Nature 436, 807-811 (11 August 2005) doi:10.1038/nature03845;
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cancer: Two in one
Anton Berns
Nature 436, 787-789 (11 August 2005) doi:10.1038/436787a;
Metastases
ARTICLE
Genes that mediate breast cancer metastasis to lung
Andy J. Minn et al.
Nature 436, 518-524 (28 July 2005) doi:10.1038/nature03799;
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Rosandra N. Kaplan et al.
Nature 438, 820-827 (8 December 2005) doi:10.1038/nature04186;
Abstract | Full Text | PDF | Supplementary Information
LETTER
A microRNA polycistron as a potential human oncogene
Lin He et al.
Nature 435, 828-833 (9 June 2005) doi:10.1038/nature03552
Cancer therapy and therapeutic targets
LETTER
A loss-of-function RNA interference screen for molecular targets in cancer
Vu N. Ngo et al.
Nature 441, 106-110 (4 May 2006) doi:10.1038/nature04687; Received 5 December 2005; Accepted 2 March 2006; Published online 29 March 2006
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cell biology: Divining cancer cell weaknesses
William G. Kaelin
Nature 441, 32-34 (4 May 2006) doi:10.1038/441032a;
LETTER
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
Andrea H. Bild et al.
Nature 439, 353-357 (19 January 2006) doi:10.1038/nature04296;
Abstract | Full Text | PDF | Supplementary Information
LETTER
BRAF mutation predicts sensitivity to MEK inhibition
David B. Solit et al.
Nature 439, 358-362 (19 January 2006) doi:10.1038/nature04304;
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cancer biology: Signatures guide drug choice
Julian Downward
Nature 439, 274-275 (19 January 2006) doi:10.1038/439274a;
LETTER
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Hannah Farmer et al.
Nature 434, 917-921 (14 April 2005) doi:10.1038/nature03445;
Abstract | Full Text | PDF | Supplementary Information
LETTER
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant et al.
Nature 434, 913-917 (14 April 2005) doi:10.1038/nature03443;
Abstract | Full Text | PDF | Supplementary Information
LETTER
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system
Shiladitya Sengupta et al.
Nature 436, 568-572 (28 July 2005) doi:10.1038/nature03794;
Abstract | Full Text | PDF | Supplementary Information
NEWS & VIEWS
Cancer: One step at a time
David Mooney
Nature 436, 468-469 (28 July 2005) doi:10.1038/436468a;