WEB FOCUS
Antimicrobials
The improvement of existing compounds and the development of new antimicrobial drugs are urgently needed in the battle against infectious diseases. A new antimicrobial, platensimycin, a small molecule manufactured by a strain of Streptomyces platensis, represents a previously unknown class of antibiotics, which acts by blocking enzymes involved in the synthesis of fatty acids. Research in this Nature Web Focus includes the discovery of new antimicrobial compounds, efforts to increase our understanding of antibiotic function and resistance, the search for additional microbial drug targets and the advancement of antimicrobial treatment strategies.
Current research
EDITORIAL
Infection biology
Nature 441, 255-256 (18 May 2006) doi:10.1038/441255b
LETTERS
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang et al.
Nature 441, 358 - 361 (18 May 2006) doi:10.1038/nature04784
Abstract | Full Text | PDF | Supplementary Information
NEWS AND VIEWS
Microbiology: Antibiotic stops 'ping-pong' match Free access
Eric D. Brown
Nature 441, 293-294 (18 May 2006) doi:10.1038/441293a
NEWS
Antibiotic faces uncertain future
Helen Pearson
Nature 441, 260-261 (18 May 2006) doi:10.1038/441260a
NEWS FEATURES
Microbiology: Batteries not included: What can't bacteria do?
Charlotte Schubert
Nature 441, 277-279 (18 May 2006) doi:10.1038/441274a
Microbiology: Batteries not included: Circuits of slime
Helen Pearson
Nature 441, 260-261 (18 May 2006) doi:10.1038/441277a
Top of page
Web links
- Microbiology@nature.com
- CDC on Antimicrobial resistance
- Bill and Melinda Gates Foundation
- Drugs for Neglected Diseases Initiative
- UNICEF/UNDP/WorldBank/WHO's TDR
- Novartis Institute for Tropical Disease
- Institute for OneWorld Health
Archive
LETTER
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae-Kyun Ro et al.
Nature 440, 940-943 (13 April 2006) doi:10.1038/nature04640
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Robust Salmonella metabolism limits possibilities for new antimicrobials
Daniel Becker et al.
Nature 440, 303-307 (16 March 2006) doi:10.1038/nature04616
Abstract | Full Text | PDF | Supplementary Information
PERSPECTIVE
Innovation: Applied systems biology and malaria
Elizabeth A. Winzeler
Nature Reviews Microbiology 4 145-151 (February 2006) doi:10.1038/nrmicro1327
Abstract | Full Text | PDF | Supplementary Information
LETTER
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Deborah Palliser et al.
Nature 439, 89-94 (5 January 2006) doi:10.1038/nature04263
OPINION
Antibody-based therapies for malaria
Richard J. Pleass & Anthony A. Holder
Nature Reviews Microbiology 3, 893-899 (2005) doi:10.1038/nrmicro1267
REVIEW
The bacterial ribosome as a target for antibiotics
Jacob Poehlsgaard & Stephen Douthwaite
Nature Reviews Microbiology 3, 870-881 (2005) doi:10.1038/nrmicro1265
Abstract | Full Text | PDF | Supplementary Information
LETTER
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
Ronald S. Veazey et al.
Nature 438, 99-102 (3 November 2005) doi:10.1038/nature04055
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
Per H. Mygind et al.
Nature 437, 975-980 (13 October 2005) doi:10.1038/nature04051
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Strategies for containing an emerging influenza pandemic in Southeast Asia
Neil M. Ferguson et al.
Nature 437, 209-214 (8 September 2005) doi:10.1038/nature04017
Abstract | Full Text | PDF | Supplementary Information
LETTER
Aminoglycoside antibiotics induce bacterial biofilm formation
Lucas R. Hoffman et al.
Nature 436, 1171-1175 (25 August 2005) doi:10.1038/nature03912
Abstract | Full Text | PDF | Supplementary Information
REVIEW
Evolution of antifungal-drug resistance: mechanisms and pathogen fitness
James B. Anderson
Nature Reviews Microbiology 3, 547-556 (2005) doi:10.1038/nrmicro1179
REVIEW
Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study
Terry A. Krulwich, Oded Lewinson, Etana Padan & Eitan Bibi
Nature Reviews Microbiology 3, 566-572 (2005) doi:10.1038/nrmicro1181
REVIEW
Regulation and biosynthesis of carbapenem antibiotics in bacteria
Sarah J. Coulthurst, Anne M. L. Barnard & George P. C. Salmond
Nature Reviews Microbiology 3, 295-306 (2005) doi:10.1038/nrmicro1128
LETTERS TO NATURE
Mediation of pathogen resistance by exudation of antimicrobials from roots
Harsh P. Bais et al.
Nature 434, 217-221 (10 March 2005) doi:10.1038/nature03356
Abstract | Full Text | PDF | Supplementary Information
PERSPECTIVE
Seeing is believing: the impact of structural genomics on antimicrobial drug discovery
Molly B. Schmid
Nature Reviews Microbiology 2, 739-746 (2004) doi:10.1038/nrmicro978
REVIEW
Antivirals and antiviral strategies
Erik De Clercq et al.
Nature Reviews Microbiology 2, 704-720 (2004) doi:10.1038/nrmicro975
Abstract | Full Text | PDF | Supplementary Information
LETTERS TO NATURE
Identification of an antimalarial synthetic trioxolane drug development candidate
Jonathan L. Vennerstrom et al.
Nature 430, 900-904 (19 August 2004) doi:10.1038/nature02779
Abstract | Full Text | PDF | Supplementary Information
