Current Issue

Volume 549 Number 7672 pp307-424

21 September 2017

About the cover

When a proliferating population of cells completes mitosis, some of the newly born daughter cells immediately enter the next cell cycle whereas other cells switch to a quiescent state. In this week's issue, Tobias Meyer and his colleagues reveal how competing memories inherited from the mother cells lead the daughter cells to decide whether to stop or start the subsequent cell cycle. Growth signals cause an accumulation of cyclin D1 messenger RNA in the mother cells, whereas DNA damage leads the cells to contain a higher amount of activated p53. These are passed on to the daughter cells, where the cyclin D1 mRNA is translated into protein and p53 promotes production of the protein p21. Daughter cells that inherit larger amounts of cyclin D1 continue through to the next cell cycle, and those that have a high amount of activated p53 move into quiescence. This results in a system of cell-cycle control that maximizes the health of growing cell populations by preferentially selecting cells with a history of low DNA damage for more frequent proliferation. Cover image: Jeroen Claus/Phospho Biomedical Animation

This Week

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    Stretchable sensors, circuits and batteries are about to change our relationships with electronics and each other, explain Bryant Chu and colleagues.

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spotlight: Young science in an old city

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  • Young science in an old city

    The political, cultural and scientific capital of the world's most populous nation is on the hunt for global talent.

    • Flynn Murphy

research

Brief Communication Arising

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Articles

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  • Rabies screen reveals GPe control of cocaine-triggered plasticity

    • Kevin T. Beier
    • Christina K. Kim
    • Paul Hoerbelt
    • Lin Wai Hung
    • Boris D. Heifets
    • Katherine E. DeLoach
    • Timothy J. Mosca
    • Sophie Neuner
    • Karl Deisseroth
    • Liqun Luo
    • Robert C. Malenka

    A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.

  • The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

    • Antonia Wallrapp
    • Samantha J. Riesenfeld
    • Patrick R. Burkett
    • Raja-Elie E. Abdulnour
    • Jackson Nyman
    • Danielle Dionne
    • Matan Hofree
    • Michael S. Cuoco
    • Christopher Rodman
    • Daneyal Farouq
    • Brian J. Haas
    • Timothy L. Tickle
    • John J. Trombetta
    • Pankaj Baral
    • Christoph S. N. Klose
    • Tanel Mahlakõiv
    • David Artis
    • Orit Rozenblatt-Rosen
    • Isaac M. Chiu
    • Bruce D. Levy
    • Monika S. Kowalczyk
    • Aviv Regev
    • Vijay K. Kuchroo

    Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

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Letters

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  • A binary main-belt comet

    • Jessica Agarwal
    • David Jewitt
    • Max Mutchler
    • Harold Weaver
    • Stephen Larson

    Analysis based on high-resolution observations from the Hubble Space Telescope shows that the asteroid 288P is a binary main-belt comet, with properties unlike any known binary asteroid.

  • 3D printing of high-strength aluminium alloys

    • John H. Martin
    • Brennan D. Yahata
    • Jacob M. Hundley
    • Justin A. Mayer
    • Tobias A. Schaedler
    • Tresa M. Pollock

    Zirconium nanoparticles introduced into aluminium alloy powders control solidification during 3D printing, enabling the production of crack-free materials with strengths comparable to the corresponding wrought material.

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  • The Apostasia genome and the evolution of orchidsOpen

    • Guo-Qiang Zhang
    • Ke-Wei Liu
    • Zhen Li
    • Rolf Lohaus
    • Yu-Yun Hsiao
    • Shan-Ce Niu
    • Jie-Yu Wang
    • Yao-Cheng Lin
    • Qing Xu
    • Li-Jun Chen
    • Kouki Yoshida
    • Sumire Fujiwara
    • Zhi-Wen Wang
    • Yong-Qiang Zhang
    • Nobutaka Mitsuda
    • Meina Wang
    • Guo-Hui Liu
    • Lorenzo Pecoraro
    • Hui-Xia Huang
    • Xin-Ju Xiao
    • Min Lin
    • Xin-Yi Wu
    • Wan-Lin Wu
    • You-Yi Chen
    • Song-Bin Chang
    • Shingo Sakamoto
    • Masaru Ohme-Takagi
    • Masafumi Yagi
    • Si-Jin Zeng
    • Ching-Yu Shen
    • Chuan-Ming Yeh
    • Yi-Bo Luo
    • Wen-Chieh Tsai
    • Yves Van de Peer
    • Zhong-Jian Liu

    Comparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.

  • A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease

    • Elvira Mass
    • Christian E. Jacome-Galarza
    • Thomas Blank
    • Tomi Lazarov
    • Benjamin H. Durham
    • Neval Ozkaya
    • Alessandro Pastore
    • Marius Schwabenland
    • Young Rock Chung
    • Marc K. Rosenblum
    • Marco Prinz
    • Omar Abdel-Wahab
    • Frederic Geissmann

    Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.

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  • cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

    • Liudmila Andreeva
    • Björn Hiller
    • Dirk Kostrewa
    • Charlotte Lässig
    • Carina C. de Oliveira Mann
    • David Jan Drexler
    • Andreas Maiser
    • Moritz Gaidt
    • Heinrich Leonhardt
    • Veit Hornung
    • Karl-Peter Hopfner

    A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

  • Alternative evolutionary histories in the sequence space of an ancient protein

    • Tyler N. Starr
    • Lora K. Picton
    • Joseph W. Thornton

    Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

  • The cryo-electron microscopy structure of human transcription factor IIH

    • Basil J. Greber
    • Thi Hoang Duong Nguyen
    • Jie Fang
    • Pavel V. Afonine
    • Paul D. Adams
    • Eva Nogales

    The cryo-electron microscopy structure of the ten-subunit human transcription factor IIH, revealing the molecular architecture of the TFIIH core complex, the detailed structures of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

Erratum

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